Protein unc-13 homolog D (Munc13-4) is involved in cytotoxic granule exocytosis in lymphocytes.
It regulates assembly of recycling and late endosomal structures which leads to the formation of an endosomal exocytic compartment.
It also regulates Ca2+-dependent secretory lysosome exocytosis in mast cells.
Munc13- 4 is highly expressed in the spleen, thymus and leukocytes and to a lesser extent in the lung and placenta, brain, heart, skeletal muscle and kidney.
Defects in Munc13-4 are the cause of hemophagocytic lymphohistiocytosis familial type 3 (FHL3).
Applications:Suitable for use in Western Blot and Immunoprecipitation.
Other applications not tested.
Recommended Dilution:Western Blot: 1:2000Immunoprecipitation: nativeOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Ascites
Purity：Ascites
Form：Supplied as a lyophilized powder. Reconstitute with 50ul sterile ddH2O.
Specificity：Recognizes human Munc13-4.
Isotype：IgG
Calc Applications Abbrev：IP WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa1-273 of human Munc13-4 at N-terminal.
