Amyloid precursor protein (APP) functions as a cell surface receptor in the synapses of neurons and is implicated in neurite growth, neuronal adhesion, axonogenesis and cell mobility.
APP is known as the precursor molecule whose proteolysis generates beta amyloid (Ab).
Defects in APP are the causes of Alzheimer’s disease type 1 and of amyloidosis cerebroarterial.
Caspase activation has been found to have a central role in neuronal death and chronic neurodegenerations such as Huntington’s, Parkinson’s and Alzheimer’s diseases.
Proteolytic cleavage of specific substrates has also been demonstrated to be an important cellular event in the pathogenesis of AD and inhibition of cleavage of APP by caspase-6 was demonstrated to suppress synapse loss, dentate gyral atrophy, and memory loss.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:5000Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months after receipt at -20°C.
Reconstitute with ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Ascites
Purity：Ascites
Form：Supplied as a lyophilized powder. Reconstitute with 50ul sterile ddH2O.
Specificity：Recognizes human Amyloid precursor protein cleaved by Caspase-6.
