アズワンのAXELショップ 試薬 特定メーカー試薬 US Biological（antibodypab）
84-3409-99 SHP2, CT (SH2 Domain-containing Protein Tyrosine Phosphatase 2, SHP-2, BPTP3, BPTP-3, CFC, MGC14433, Noonan Syndrome 1, Noonan Syndrome 1 Protein Tyrosine Phosphatase 2C, NS1, Protein Tyrosine Phosphatase 2C, PTP2C, PTP-2C, Protein Tyrosine Phosphatase Non-receptor Type 11, PTPN11, PTP1D, PTP-1D, SHIP2, SHPTP2, SH-PTP2, SHPTP3, SH-PTP3, SIT Protein Precursor, Syp, Tyrosine Protein Phosphatase ... S1013-30M-ML490
84-3409-99 SHP2, CT (SH2 Domain-containing Protein Tyrosine Phosphatase 2, SHP-2, BPTP3, BPTP-3, CFC, MGC14433, Noonan Syndrome 1, Noonan Syndrome 1 Protein Tyrosine Phosphatase 2C, NS1, Protein Tyrosine Phosphatase 2C, PTP2C, PTP-2C, Protein Tyrosine Phosphatase Non-receptor Type 11, PTPN11, PTP1D, PTP-1D, SHIP2, SHPTP2, SH-PTP2, SHPTP3, SH-PTP3, SIT Protein Precursor, Syp, Tyrosine Protein Phosphatase ... S1013-30M-ML490
特徴
MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection.
Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000.
SHP2 is a 68kD member of the protein tyrosine phosphatase family.
SHP2 acts downstream of growth factor receptors and cytoplasmic protein tyrosine kinases which transduce signals from cell surface to the nucleus.
The recruitment and activation of SHP2 is mediated through the binding of CD172a to its ligand CD47.
SHP2 regulates a variety of cellular processes.
These include transcription, embryonic development, cell growth, cell migration, differentiation, mitotic cycle, haematopoiesis and oncogenic transformation.
As a result, dysregulation of the SHP2 gene has been linked to LEOPARD, Noonan and Noonan-like syndrome as well as acute myeloid leukaemia.
SHP2 is ubiquitously expressed, with highest levels found in heart, brain, and skeletal muscle.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C in the dark.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: MaxLight™490 conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490.
Specificity：Recognizes human SHP2 at ~68kD in skeletal muscle tissue lysate. Species Crossreactivity: mouse, rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：14aa peptide sequence near the carboxy terminus of human SHP2.
Shelf Life：1year
Swiss Prot Number：Q06124
EU Commodity Code：30021010
商品名：SHP2, CT (SH2 Domain-containing Protein Tyrosine Phosphatase 2, SHP-2, BPTP3, BPTP-3, CFC, MGC14433, Noonan Syndrome 1, Noonan Syndrome 1 Protein Tyrosine Phosphatase 2C, NS1, Protein Tyrosine Phosphatase 2C, PTP2C, PTP-2C, Protein Tyrosine Phosphatase Non-receptor Type 11, PTPN11, PTP1D, PTP-1D, SHIP2, SHPTP2, SH-PTP2, SHPTP3, SH-PTP3, SIT Protein Precursor, Syp, Tyrosine Protein Phosphatase Non-receptor Type 11) (MaxLight 490) 100ul
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【試薬に関するお問合せ】
アズワン株式会社 試薬・プロセス材料グループ
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FAX：06-6447-8642
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