Presenilin enhancer protein 2 (PEN), a 12kD member of the PEN2 family and subunit of the gamma-secretase complex.
This complex is an endoprotease that cleaves integral membrane proteins.
These include Notch receptors and the beta-amyloid precursor protein which is cleaved to form amyloid beta peptide, a major component of the neuritic plaques found in Alzheimer’s disease.
The gamma secretase complex consists of nicastrin, the presenilin homodimers and APH1.
It is the addition of PEN2, the final stage of gamma secretase maturation that facilitates endoproteolysis of presenilin and confers proteolytic activity.
PEN2 expression has been observed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C in the dark.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: PE conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. Labeled with R-Phycoerythrin (PE).
Specificity：Recognizes human PEN2. Species Crossreactivity: mouse, rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：13 amino acid peptide sequence near the amino terminus of human PEN2.
