Parathyroid hormone related peptide (PTHrP), is a ubiquitously produced neuroendocrine polypeptide hormone, which signals through Parathyroid Hormone Receptor 1 (PTHR1), and acts as a critical regulator of cellular and tissue development, cell differentiation and migration, calcium and phosphorous extracellular concentrations, bone, teeth, and mammary gland development, and epithelial calcium ion transport.
Studies have shown the involvement of PTHrP during the metastasis of colon cancer cells, identifying a positive correlation between PTHrP, Rac1 activity, the guanine nucleotide exchange factor Tiam1, and integrin alpha6beta4.
Elevated expression of PTHrP is most commonly associated with breast cancer, and also with gastrointestinal (GI) tumors.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 0.5-2.0ug/mlWestern Blot: 0.1-0.2ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C in the dark.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: PE conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. Labeled with R-Phycoerythrin (PE).
Specificity：Recognizes human Parathyroid hormone related peptide.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human PTHrP.
