84-3401-46　FLIP, CT (FLICE Inhibitory Protein) (PE) 100ul　F4550-01-PE

特徴

• FLICE-inhibitory proteins (FLIP) are widely expressed apoptosis regulator proteins.
• FLIPs may function as a crucial link between cell survival and cell death pathways in mammalian cells.
• At least 14 isoforms of FLIP have been defined arising from alternative splicing.
• The long form FLIP-L contains a domain similar to those found in caspases.
• FLIP was cloned independently in a number of laboratories and is also known as Casper, I-FLICE, FLAME-1, CASH and CLARP.
• FLIP has two death effector domains (DEDs) and a caspase-like domain.
• It interacts with FADD and caspase-8 and -10, potently inhibiting apoptosis by all known death receptors.
• FLIP exists in a short form (FLIPS) and a long form (FLIPL).
• Applications: Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: Frozen sectionsOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C in the dark.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: PE conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.