84-3389-84　［取扱停止］Toso, CT (Regulator of Fas-induced Apoptosis, Fas Apoptotic Inhibitory Molecule 3, FAIM3) (AP) 100ul　T8067-50C-AP

特徴

• Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3).
• Toso is expressed by lymphoid and hematopoietic cells and is up-regulated by T-cell activation.
• Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis.
• Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation.
• Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases.
• Despite its predicted molecular weight, Toso often migrates at 60kD in SDS PAGE.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/ml detects a band of ~43kD in human lung tissue lysate
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.