84-3386-90　［取扱停止］BAFF (B cell Activating Factor belonging to TNF Family, BLyS, TALL-1, THANK) (AP) 100ul　B0003-65-AP

特徴

• Members in the TNF superfamily regulate immune responses and induce apoptosis.
• A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4.
• BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion.
• Two receptors, TACI and BCMA, for BAFF were originally identified.
• A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3.
• Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival.
• BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-£eB and c-jun N-terminal kinase.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilution determined by the researcher.
• Storage and Stability:Store product at 4°C.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.