84-3382-91　［取扱停止］Rac1 (Ras-related C3 Botulinum Toxin Substrate 1, Cell Migration-inducing Gene 5 Protein, MGC111543, MIG5, p21-Rac1, Ras-like Protein TC25, TC25, TC-25, MIG5) (MaxLight 650) 100ul　217732-ML650

特徴

• MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection.
• Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000.
• Rac is a member of the Rho family of small GTP-binding proteins.
• It plays roles in cytoskeletal actin organization as well as transformation along with its other Rho family members.
• Rac, Rho, and Cdc42 all work in concert with one another in the assembly of actin-based structures such as lamellipodia, stress fibers, and filopodia, respectively to control cell migration.
• Rac is activated downstream of cdc42, or independently by Ras signaling, and in turn Rac stimulates Rho.
• Effectors of the Rac pathway include NADPH Oxidase and the SAPK1/JNK family of kinases.
• The latter pathway is activated by the PAK kinases, which are direct targets of Rac.
• Rac1b is a highly active splice varient of Rac1.
• It differs in that it has an additional 19aa.
• It has been found in various tumors such as breasts and colorectal.
• Applications:Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: ParaffinOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C in the dark.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: MaxLight™650 conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.