84-3372-82　［取扱停止］GFR alpha3 (Glycosylphosphadidylinositol linked Protein, GDNFRg, Ret ligand 3, RETL3) (MaxLight 490) 100ul　G2033-52-ML490

特徴

• MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection.
• Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000.
• Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation.
• A new member of the GDNF family was recently identified and designated persephin (Milbrandt et al.
• 1998).
• Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb (Nomenclature Committee 1997).
• Following the findings of GFRa-1 and -2, a novel receptor in GFRa family was identified very recently from human and mouse and designated GFRa-3 (Jing et al.
• 1997; Baloh et al.
• 1998; Worby et al.
• 1998; Navelthan et al.
• 1998; Nomoto et al.
• 1998).
• GFRa-3 binds persephin, thus, persephin, GFRa-3 and the Ret PTK form a complex to transduce persephin signal and to mediate persephin function.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilution determined by the researcher.
• Positive Control: Mouse kidney, liver or heart tissue lysates
• Storage and Stability:Store product at 4°C in the dark.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: MaxLight 490 conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.