TACC2, also known as transforming acidic coiled-coil-containing protein 2, belongs to the transforming acidic coiled-coil-containing (TACC) protein family.
This group of proteins is defined by its highly conserved coiled-coil domain.
This domain is necessary for the assignment of the centrosome-spindle apparatus during cell cycling.
There are three proteins belonging to the TACC family; TACC1, TACC2, and TACC3.
TACC2 has been reported as playing a necessary role in cultured cell microtubule stabilization.
It has also been shown that the binding of TACC2 by T antigen can cause chromosomal instability and mitotic defects (Tei, 2009).
Research into the over expression of TACC2 strongly suggests a potential function as a tumor suppressor (Tei, 2009).
Applications:Suitable for use in Western Blot.
Other applications have not been tested.
Recommended Dilutions:Western Blot: detects TACC2 on 10ug of mouse testis tissue lysateOptimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C in the dark.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: PE conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Specificity：Recognizes mouse TACC2, Mr ~65kD. TACC2 has a reported Mr ~73kD in HeLa cell lysates. The immunizing peptide inhibited antibody recognition of the Mr ~65kD band in a competition experiment. Species Crossreactivity: human
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo
Immunogen：Linear peptide corresponding to the mature chain of mouse TACC2, conjugated to KLH. Species Sequence Homology: rat
