Apolipoprotein C-III (ApoC-III) has been shown to be an essential part of the metabolism of triglyceride-rich lipoproteins.
ApoC-III is thought to exist in three different isoforms (ApoC-III0, ApoC-III1, and ApoC-III2) based on the sialylation degree.
The primary CIII1 and CIII2 isoforms, contribute to hypertriglyceridemia and that apoC-III2 may be important in the expression of the small, dense LDL phenotype.
Regulating apoC-III metabolism could be a promising new therapeutic approach to managing dyslipidaemia and cardiovascular disease risk in the metabolic syndrome.
ApoC-III has been found to be over-expressed in patients with uremia.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).
Specificity：Recognizes human Apolipoprotein C-III at the N-terminal domain. Species Crossreactivity: chimpanzee.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Linear peptide corresponding to the N-terminal domain of human Apolipoprotein C-III, conjugated to KLH.
