84-3363-67　FOXP1 (Forkhead Box P1, 12CC4, FLJ23741, Forkhead Related Protein-like B, hFKH1B, Glutamine Rich Factor 1, HSPC215, MGC12942, MGC88572, MGC99551, QRF1) (HRP) 100ul　F9049-98D-HRP

特徴

• Forkhead box protein 1 (FOXP1) is a member of the Forkhead family of transcription factors, which have been characterized as transcriptional repressors and activators, and as having a DNA-binding domain distinguished by its formation of a winged-helix motif.
• FOXP1 is known to be an important regulator of airway morphogenesis, lung epithelial development, and early cardiac development.
• It is also known to have an important role in conjunction with NFκβ in the development of B-cells and the differentiation of macrophages.
• Splice variants give rise to four isoforms of FOXP1.
• The protein is known to form homodimers and heterodimers with FOXP2 and FOXP4.
• Studies have indicated FOXP1 as a potential inducer of oncogenesis when over expressed.
• The depletion and mutation of FOXP1 expression may lead to defects in embryonic cardiac, lung and esophagus epithelial development.
• Applications: Suitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Positive Control:linear peptide corresponding to the C-terminus of human FOXP1.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.