Apolipoprotein C-III (ApoC-III) has been shown to be an essential part of the metabolism of triglyceride-rich lipoproteins.
ApoC-III is thought to exist in three different isoforms (ApoC-III0, ApoC-III1, and ApoC-III2) based on the sialylation degree.
The primary CIII1 and CIII2 isoforms, contribute to hypertriglyceridemia and that apoC-III2 may be important in the expression of the small, dense LDL phenotype.
Regulating apoC-III metabolism could be a promising new therapeutic approach to managing dyslipidaemia and cardiovascular disease risk in the metabolic syndrome.
ApoC-III has been found to be over-expressed in patients with uremia.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Formalin fixed paraffin embedded): 1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Specificity：Recognizes human Apolipoprotein C-III at the N-terminal domain. Species Crossreactivity: chimpanzee.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Linear peptide corresponding to the N-terminal domain of human Apolipoprotein C-III, conjugated to KLH.
