PR domain proteins (PRDMs) have been associated with many types of human cancers.
PRDM14 was found to be up-regulated in breast cancer cells.
The expression of PRDM14 to breast cancer cells actually increased cell proliferation and decreased the effect of chemotherapeutic drugs, while down-regulation of PRDM14 did the opposite.
In addition to breast cancer, PRDM14 has recently been linked to non-small cell lung cancer development.
PRDM14 also seems to play a role in the preservation of the self-renewal of human embryonic stem cells and transcriptional regulation.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
Positive Control:Human lung tissue lysate
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Specificity：Recognizes human PRDM14. Species Crossreactivity: Mouse and rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to the N-terminus of human PRDM14, fused to GST-Tag.
