Glycine receptor a3 subunit, also known as GLRA3, belongs to the ligand-gated ion channel family.
Glycine functions as a inhibitory neurotransmitter throughout the CNS of mammals.
The Glycine receptor is a neurotransmitter ligand-gated ion channel.
GLRA3 is a pentamer that is composed of ligand binding alpha and structural beta subunits.
When glycine binds to the receptor, chloride conductance increases which produces hyperpolarization.
It is expressed in the hippocampus, olfactory bulb, and cerebellum.
GLRA3 may be involved in human and murine neurological disorders.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:Immunohistochemistry (Paraffin): HIER using sodium citrate buffer pH 6.0Optimal dilutions to be determined by the researcher.
Positive Control:Fetal human brain tissue lysate
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Specificity：Recognizes human Glycine Receptor a3 subunit at ~48kD. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide from the C-terminus of human GLRA3, conjugated to KLH. Cellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Species Sequence Homology: rat, 92%
