Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family.
Five members have been identified in the arginine methyltransferase family.
About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family.
The retinoblastoma protein-interacting zinc finger gene RIZ1 is a tumor suppressor gene and the founding member of the PR domain family.
PRDM12 (PR domain zinc finger protein 12) also acts as a tumor suppressor and is linked to the pathogenesis of chronic myeloid leukemia.
PRDM12 is also thought to play a role in transcriptional regulation.
Applications:Suitable for use in Western Blot and Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Positive Control:Human liver tissue lysate
Storage and Stability:Store product at 4°C.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Specificity：Recognizes human PRDM12. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：IC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic linear peptide corresponding to human PRDM12, conjugated to KLH.
