The majority of rapid excitatory transmission in the nervous system is mediated by glutamate-activated ion channels.
Ionotropic glutamate receptors have been subdivided pharmacologically into AMPA (cx-amino-3-hydroxy-5methyl-Cisoxazole propionic acid), KA (kainate), and NMDA subtypes (Monaghan et al., 1989).
These receptors have been implicated in a number of physiological and pathological processes.
During development glutamate receptors are involved in neuronal differentiation, migration, and activity-dependent synapse formation (Balazs et al., 1989; Brewer, 1989; Komoru and Rakic, 1993).
In mature neurons, long-term potentiation and long-term depression require ionotropic glutamate receptors.
Glutamate-gated ion channels also play a central role in mediating the excitotoxic effects of glutamate (Olney, 1990).
Pathophysiological processes thought to involve glutamate excitotoxicity and neurodegeneration include epilepsy stroke, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:5000Optimal dilutions to be determined by the researcher.
Positive Control:Rat cerebellum tissue lysate and human cerebellum tissue lysate
Storage and Stability:Store product at 4°C.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Specificity：Recognizes the C-Terminus of Glutamate receptor delta 1 and delta 2. Species Crossreactivity: rat and human. Reacts weakly with mouse.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Rt
Immunogen：Synthetic linear peptide to the C-Terminus, conjugated to BSA. Cellular Localization: Cell membrane; Multi-pass membrane protein. Species sequence homology: primates.
