84-2746-13　［取扱停止］BMPR2, NT (Bone morphogenetic protein receptor type-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, PPH1) (MaxLight 405) 100ul　032551-ML405

特徴

• MaxLight™405 is a new Violet photostable dye conjugate comparable to Alexa Fluor® 405, PacificBlue™, Brilliant™ Violet 421 and offers better labeling efficiency, brighter imaging and increased immunodetection.
• Absorbance (400nm); Emission (423nm); Extinction Coefficient 32,000.
• BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases.
• The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily.
• BMPs are involved in endochondral bone formation and embryogenesis.
• These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD.
• Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
• Mutations in BMPR2 have been associated with primary pulmonary hypertension.
• Applications:Suitable for use in Immunohistochemistry, Flow Cytometry (Not Tested) and FLISA.
• Other applications have not been tested.
• Recommended Dilutions:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C in the dark.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: MaxLight™405 conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.