84-2655-42　Visinin-Like Protein 1 (VSNL1, VLP-1) 100ul　299564

特徴

• Visinin-like protein 1 (VSNL1) is a small Calcium binding protein which is very abundant in the nervous system and is found only in neurons, though different neurons have different levels of expression.
• It is particularly concentrated in cerebellar Purkinje cells, and tends to be most abundant in perikarya and dendrites.
• The protein was discovered independently by several groups and is therefore also sometimes known as hippocalcin-like protein 3, HLP3, HPCAL3, HUVISL1, VLP-1, VILIP and VILIP-1.
• The protein belongs to the large superfamly of calmodulin and paravalbumin type proteins which function by binding Calcium ions.
• Calcium binding alters the confomation of these proteins and allow them to interact with other binding partners, the properties of which they may alter.
• Visinin-like protein 1 has four "EF hand" domains, which are negatively charged helix-turn-helix peptides which are responsible for Calcium binding.
• Visinin-like protein 1 is 191aa in size and has a molecular weight on SDS-PAGE of ~22kD.
• The protein has recently been suggested to be a useful biomarker of Alzheimer's disease and traumatic brain injury.
• Applications:Suitable for use in Immunofluorescence and Western Blot.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 1:1000-2000 Western Blot: 1:5000-10,000 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.