This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases.
It is a component of the mitochondrial network.
Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness.
Eight transcript variants encoding different isoforms, resulting from alternative splicing of exon 4 and two novel exons named 4b and 5b, have been reported for this gene.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 2ug/mlImmunohistochemistry: 2.5ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Human Brain Lysates
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.05% sodium azide.
Specificity：Recognizes human OPA1. Species Crossreactivity: mouse, rat, chicken
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Ch Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa500-600 from the internal region of human OPA1.
