Neurogranin is a calmodulin-binding protein expressed exclusively in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway.
Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium.
Phosphorylation by protein kinase C lowers its binding ability.
Neurogranin is down regulate in Schizophrenia and is not found in the dendrites in patients with Alzheimer disease.
Applications:Suitable for use in Peptide ELISA, Western Blot and Immunohistochemistry.
detects ~16kD band observed in Human Brain (Frontal Cortex)Immunohistochemistry (Paraffin): 5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by ammonium sulfate precipitation followed by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human Neurogranin.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to C-KIKSGERGRKG, from the internal region of human Neurogranin. Species sequence homology: mouse, canine and bovine
