Recognizes a variety of advanced glycated end product (AGE) epitopes.
Glycation is the post-translational modification of proteins, linking a reducing sugar to an amino group on a protein.
AGEs are thought to be involved in structural and functional alterations of proteins observed in aging and diabetes.
AGEs recognised include carboxymethyllysine and pentosidine.
Increases in pentosidine levels are associated with aging, diabetes, cataracts, renal diseases, chronic rheumatoid arthritis, photaged skin and Alzheimers disease.
Carboxymethyllysine is involved in uracemia.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:ELISA: 1:200-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：10ug
Host：goat
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder in 75mM PBS, pH 7.2, 75mM sodium chloride, 0.5mM EDTA, 0.02% sodium azide. Reconstitute with sterile ddH2O.
Specificity：Recognizes Advanced Glycosylation Endproduct. Specifically binds to CML modified proteins.
