84-2592-69 PDE4D (DKFZp686M11213, DPDE3, FLJ97311, HSPDE4D, PDE4DN2, STRK1) 50ul 254230
特徴
- Phosphodiesterases (PDE) hydrolyze cAMP to 5’AMP and thus play a critical role in the regulation of intracellular cAMP.
- Division of the PDE superfamily by sequence homology and enzymatic properties yields 11 PDE families.
- A unique upstream conserved region (UCR) characterizes the PDE4 family.
- Four separate genes (A-D) encode the PDE4 enzymes, and alternative splicing generates short or long isoforms of each gene.
- Long PDE4 isoforms contain both UCR1 and UCR2 while short PDE4 isoforms possess only UCR2.
- Both UCR domains are necessary for dimerization of PDE4 isoforms.
- The human PDE4D gene maps to chromosome 5q12.
- Applications:Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry.
- Other applications not tested.
- Recommended Dilution:Western Blot: 1:2000 Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for 12 months after receipt.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：50ul
- Host：rabbit
- Source Antibody：human
- Grade：Serum
- Purity：Serum
- Form：Supplied as a liquid.
- Specificity：Recognizes members of the PDE4D sub-family Species Crossreactivity: Mouse, Rat, Human
- Isotype：IgG
- Calc Applications Abbrev：IHC IP WB
- Calc Crossreactivity：Hu Mo Rt
- Immunogen：Designed from the C-terminal region common to all 4D isoforms
- Shelf Life：1year
- EU Commodity Code：30021010
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