84-2592-27　［取扱停止］Emerin (EDMD, EMD, Emery Dreifuss muscular dystrophy, STA) 50ul　254031

特徴

• Stabilizes and promotes the formation of a nuclear actin cortical network.
• Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments.
• Inhibits beta-catenin activity by preventing its accumulation in the nucleus.
• Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway.
• Links centrosomes to the nuclear envelope via a microtubule association.
• EMD and BAF are cooperative cofactors of HIV-1 infection.
• Association of EMD with the viral DNA requires the presence of BAF and viral integrase.
• The association of viral DNA with chromatin requires the presence of BAF and EMD.
• Required for proper localization of non-farnesylated prelamin-A/C.
• Applications:Suitable for use in Immunofluorescence, Western Blot, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000.
• Predicted molecular weight: 29kD.
• Immunocytochemistry/Immunofluorescence: 1:100 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.