DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation.
Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator.
Binds DNA.
In vitro, has double-stranded DNA-dependent ATPase activity.
Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.
Applications:Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry(Paraffin): 5ug/ml Immunoprecipitation: 2-10ug/mg lysateOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris-citrate/phosphate, pH 7-8, 0.09% sodium azide.
Specificity：Recognizes region between residue 1400 and 1450 of human INO80. Species Crossreactivity: mouse, rat, bovine, canine, equine, porcine, rabbit
