D-amino acid oxidase (DAAO) metabolizes exogenous D-amino acids that accumulate during aging and modulates the level of D-serine in the brain, acting as a detoxifying agent.
DAAO is specific for the D-configuration of amino acids and exhibits a preference for those with small, hydrophobic side chains and polar, aromatic and basic functional groups.
D-amino acid oxidase activator (G72) associates with and activates DAAO.
This 157 amino acid protein localizes to the Golgi apparatus.
The gene encoding for the protein, known as DAOA, maps to chromosome 13q33.2-13q34.
G72 is expressed in amygdala, spinal cord and testis.
The G72 protein, together with the associated protein DAAO, is often implicated in schizophrenia.
An overexpression of the G72 protein can be detected in schizophrenic brain samples.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Labeled with horseradish peroxidase (HRP).
Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
HRP conjugates are sensitive to light.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with horseradish peroxidase (HRP).
Specificity：Recognizes human DAOA.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human DAOA.
