STXBP1 (Syntaxin-binding protein 1; also p67, Munc18-1, N-Sec1 and Unc18A) is a 67kD member of the SNARE-interacting Sec1/Unc18/STXBP family of proteins.
It is expressed in a variety of cells, presumably in those that exhibit granule exocytosis, and likely participates in (synaptic) granule release.
Ligands for STXBP1 include STX1A, 2 and 3, and it is possible that STXBP1 both suppresses STX activity, and serves as an anchor for STX-mediated vesicle fusion.
Human STXBP1 is 594aa in length.
It contains one SEC1 domain (aa41-575).
Phosphorylation at Ser313 may stimulate granule release.
There is one splice variant that shows a 28aa substitution for aa576-594.
This is restricted to neural tissue.
Over aa80-226, human and mouse STXBP1 are absolutely identical in amino acid sequence.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap.
Storage and Stability:Store product at 4°C.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Purified
Purity：Purified.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).
Specificity：Recognizes human STXBP1. Species Crossreactivity: mouse.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo
Immunogen：STXBP1 (NP_003156.1, 1-603aa) full-length human protein.
