The Myc-associated zinc finger protein MAZ (also designated ZF87, and Pur-1 in mouse) is a transcription factor that participates in both the initiation and termination of transcription of target genes.
MAZ functions as a true transcriptional repressor in that it represses transcription independent of the c-Myc promoter.
Both MAZ and SP1 bind to the parathyroid hormone (PTH)/ PTH-related peptide receptor promoter, thereby influencing the cell-specific expression of its gene product.
MAZ and SP1 also regulate expression from the serotonin 1A receptor gene promoter, suggesting that MAZ may act on a variety of promoters through G-C rich sequences, which serve as binding sites for the SP1 family of transcription factors.
Competition between SP1 and MAZ control tissue-specific expression of the PNMT gene.
The interaction of MAZ with the transcriptional repressor FAC1 may affect gene regulation in neurodegeneration.
MAZ also acts as a growth suppressor protein, in part by affecting the levels of key cell cycle regulatory proteins such as cyclin A and E.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 15mM sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of ZNF801. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 201-246 of Human ZNF801.
