Zinc finger genes that encode metal-binding proteins are transcriptional regulators of other genes.
Myeloid zinc finger 1 (MZF-1), also designated Zinc finger protein 42, and transcription factor ZBP-89, also designated Zinc finger protein 148, belong to the Krueppel C2H2-type zinc-finger protein family.
The gene encoding for the MZF-1 protein maps to chromosome 19q13.43 while the gene encoding for ZBP-89 is localized on chromosome 3q21.
These proteins are nuclear proteins involved in the regulation of transcriptional events.
MZF-1 regulates transcription during hemopoietic development and plays a role in myeloid cell differentiation.
MZF-1 regulates the CD34 promoter in a tissue-specific manner.
MZF-1 and FHL3 can form a complex of high molecular mass with other proteins in the nucleus.
It is induced by retinoic acid and is primarily expressed in differentiating myeloid cells.
Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Immunocytochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of ZNF42. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IC IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 1-46 of Human ZNF42.
