Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression.
ZNF262, also known as ZMyM4, is a 1,548 amino acid protein that contains 9 MyM-type zinc fingers.
Four ZNF262 isoforms are expressed due to alternative splicing events, and are found in heart, skeletal muscle, kidney and liver.
Upon DNA damage, ZNF262 may be phosphorylated by ATM or ATR.
The mRNA encoding ZNF262 contains a CDIR motif (cell death inhibiting RNA) which binds to HNRPD/AUF1 and HSPB1/HSP27 and can inhibit FN-y induced apoptosis.
The gene encoding ZNF262 maps to chromosome 1, which spans about 260 million base pairs and comprises nearly 8% of the human genome.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of ZNF262. Species Crossreactivity: Human, mouse
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to amino acids 804-856 of Human ZNF262.
