84-2414-16　［取扱停止］ZMYND11 (Zinc Finger MYND Domain-Containing Protein 11, Adenovirus 5 E1A-Binding Protein, Bone morphogenetic Protein Receptor-Associated Molecule 1, Protein BS69, ZMYND11, BRAM1, BS69) 100ul　226756

特徴

• The adenovirus E1A gene products are nuclear phosphoproteins with the ability to transactivate other adenovirus genes.
• BS69 specifically interacts with adenovirus 5 E1A and inhibits transactivation by the 289R E1A protein.
• BS69 interacts with the co-repressor N-CoR through an essential MYND domain in the carboxy terminus of N-CoR.
• BS69 also inhibits the transcriptional activity of c-Myb.
• During oncogenesis, this BS69/Myb regulatory circuit maybe be a target for disruption .
• Another ubiquitously expressed member of the Myb gene family, b-Myb, also interacts with BS69 and N-CoR to function as a transcriptional repressor.
• BRAM1, a splice variant of BS69, binds specifically to bone morphogenetic protein type IA receptor (BMPR-IA).
• BRAM1 localizes to the cytoplasm of mammalian cells, while BS69 localizes to the cell nucleus .
• Unlike BS69, BRAM1 is unable to repress transcription .
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.