84-2413-08　［取扱停止］Wnt2 (Int 1 Related Protein, Int-1-like Protein 1, Int-1-Related Protein, INT1L 1, INT1L1, IRP, IRP Protein, Oncogene INT1 LIKE 1, Protein Wnt-2, Secreted Growth Factor, Wingless Type MMTV integration site Family Member 2, WNT 2, WNT2, WNT2_HUMAN) 50ul　226703

特徴

• Products of the highly conserved Wnt gene family, including Wnt-1 through Wnt-10, play key roles in regulating cellular growth and differentiation.
• Wnt-1 is a cysteine-rich, secreted glycoprotein that associates with cell membranes and likely functions as a key regulator of cellular adhesion.
• Wnt-1, which is essential for normal development of the embryonic nervous system, contributes to hyperplasia and tumorigenic progression when improperly expressed in mammary tissue.
• Wnt-3 is also involved in tumorigenesis and Wnt-2 and Wnt-4 may be associated with abnormal proliferation in human breast tissue.
• Wnt-1, Wnt-3 and Wnt-10b have been implicated along with FGF-3 in the development of mouse mammary tumor virus induced mouse mammary carcinomas.
• Wnt family members have been shown to interact with Sonic hedgehog (Shh) in vivo to induce myogenesis in somatic tissue.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.