The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors.
Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects.
Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 15mM sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of VDR, phosphorylated S208. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic phosphopeptide derived from human VDR around the phosphorylation site of Serine 208.
Shelf Life：1year
Swiss Prot Number：P11473
EU Commodity Code：30021010
商品名：VDR, phosphorylated (S208) (1 25 dihydroxyvitamin D3 Receptor, 1, 1, 25-@dihydroxyvitamin D3 Receptor, 125 dihydroxyvitamin D3 Receptor, 25-dihydroxyvitamin D3 Receptor, Member 1, NR1I1, Nuclear Receptor Subfamily 1 group I Member 1, VDR, VDR, Vitamin D (1, 25- dihydroxyvitamin D3) Receptor, Vitamin D Hormone Receptor, Vitamin D Nuclear Receptor Variant 1, Vitamin D Receptor, Vitamin D3 Receptor, Vitamin D3 Receptor, Vitamin D3 Receptor) 50ul
