UDP-glucuronosyltransferase isoenzymes (UGTs) catalyze the glucuronidation of small lipophilic molecules, thereby regulating the bioactivity and metabolic fate of a wide range of endogenous compounds and xenobiotics.
Glucuronidation increases the polarity of lipophilic molecules and facilitates their entry into aqueous compartments and, ultimately, their excretion.
In essence, glucuronidation provides a protective function by terminating or attenuating the biological activity of its substrates.
The UGT2B family of isoenzymes are highly expressed in liver, but are also detected in several non-hepatic tissues, including skin, breast, prostate, intestine, placenta and lung.
UGT2B7 (UDP-glucuronosyltransferase 2B7), also known as UGTB2B9, is a 529 amino acid singlepass membrane protein that localizes to both the microsome and the endoplasmic reticulum and belongs to the UDP-glycosyltransferase family.
Exhibiting a unique specificity for 3,4-catechol estrogens and estriol, UGT2B7 is thought to play an important role in the regulation of both the level and the activity of estrogen metabolites.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of UGT2B7. Species Crossreactivity: Human
