84-2410-69　［取扱停止］UGT1A1 (Bilirubin specific UDPGT Isozyme 1, bilirubin UDP glucuronosyltransferase 1 1, bilirubin UDP glucuronosyltransferase Isozyme 1, Bilirubin-specific UDPGT Isozyme 1, EC 2.4.1.17, GNT1, HUG BR1, HUG-BR1, HUGBR1, PHENOL/BILIRUBIN UDP GLUCURONOSYLTRANSFERASE, UD11_HUMAN, UDP glucuronosyltransferase 1 1 [Precursor], UDP glucuronosyltransferase 1 Family Polypepti ...　226581

特徴

• The human UDP-glucuronosyltransferase 1 (UGT1) locus encodes at least ten UGT1A proteins (UGT1A1-UGT1A10) that play a prominent role in drug and xenobiotic metabolism.
• Research indicates that nuclear receptors such as pregnane X receptor (PXR), constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor (PPAR) can regulate UGTs, which may contribute to the tissue-specific expression pattern of UGTs.
• Deficiency in the expression and/or activity of UGTs may lead to genetic and acquired diseases such as Crigler-Najjar syndrome and Gilbert syndrome.
• Based on their ability to catalyze the glucuronidation of xenobiotics and endobiotics, UGTs play a critical role in hormonal homeostasis, energy metabolism, bilirubin clearance and xenobiotic detoxification.
• UDP-glucuronosyltransferase 1A1 (UGT1A), also designated Bilirubin specific UDPGT isozyme 1 (HUG-BR1), is crucial in the conjugation and elimination of toxic zenobiotics and endogenous compounds.
• Defects in UGT1A1 may cause transient familial neonatal hyperbilirubinemia associated with breast milk, which is characterizied by excessive concentration of bilirubin in the blood, leading to jaundice.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.