84-2410-49　［取扱停止］UCN (Urocortin) 50ul　226571

特徴

• Urocortins 1, 2 and 3 are the mammalian homologs of fish urotensin I.
• Mammalian urocortin is a member of the corticotropin-releasing hormone(CRH) family that is expressed in a region of the rat midbrain.
• The distinct expression pattern in discrete brain regions suggests that it influences such behavior as feeding, anxiety and auditory processing.
• Synthetic human urocortin binds with high affinity to CRH receptors and acts in vitro to release ACTH from dispersed rat anterior pituitary cells.
• It is suggested that urocortin may be an endogenous CRF-like factor in the brain responsible for the effects of stress on appetite.
• The gene which encodes urocortin maps to human chromosome 2.
• Specifically, urocortin III is a specific ligand for CRF type 2 receptor which mediates stress-coping responses.
• Human urocortin I and III are expressed in the human heart.
• Urocortin III is also expressed in the pituitary gland, adrenal gland, GI tract, ovary, spleen, brain and kidney.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.