84-2410-01　［取扱停止］UBAP2L (Ubiquitin-Associated Protein 2-like, Protein NICE-4, KIAA0144, NICE4) 50ul　226546

特徴

• NICE4, also known as UBAP2L (Ubiquitin-associated protein 2-like) orKIAA0144, is a 1,087 amino acid protein that is ubiquitously expressed.
• Phosphorylated upon DNA damage, NICE4 contains one UBA domain and is expressed as 4 isoforms produced by alternative splicing events.
• The gene that encodes NICE4 maps to human chromosome 1.
• Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.
• There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1.
• Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes Lamin A.
• When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs.
• The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration.
• The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis.
• Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.
• Applications:Suitable for use in Western Blot, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunocytochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.