84-2409-67　［取扱停止］TWIK-1 (Potassium Channel Subfamily K Member 1, Inward rectifying Potassium Channel Protein TWIK-1, Potassium Channel KCNO1, KCNK1, HOHO1, KCNO1, TWIK1) 100ul　226528

特徴

• K+ channels are divided into three subclasses, reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS.
• Members of the 4TMS class contain two distinct pore regions, and include TASK, TREK, TRAAK and TWIK.
• TWIK-1 mRNA is expressed abundantly in brain and at lower levels in lung, kidney and skeletal muscle.
• The molecular weight of TWIK-1 in mouse brain is 40kDa under reducing conditions.
• TWIK-2 shares low sequence homology with other mammalian family group members, and only 34% homology with TWIK-1.
• Human TWIK-2 is expressed in pancreas, placenta and heart, while mouse TWIK-2 is expressed in liver.
• TWIK-2 is inhibited by intracellular, but not extracellular, acidification.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.