Phemx (pan-hematopoietic expression protein), also known as PHMX, TSPAN32 (tetraspanin-32) or TSSC6 (tumor-suppressing subtransferable candidate 6), is a member of the tetraspanin (TM4SF) family of proteins that may be involved in transmembrane signal transduction, regulation of cell proliferation, differentiation and motility.
Phemx is a multi-pass membrane protein containing intracellular N- and C-terminal domains, four transmembrane domains and two extracellular loops.
It is ubiquitously expressed from early embryogenesis through adulthood.
Phemx exhibits predominant expression in hematopoietic tissues suggesting a role in hematopoietic-cell function.
In association with the Integrin alphaIIb/Integrin beta3 complex, Phemx functions to stabilize arterial thrombi in platelets and regulate “outside-in” signaling.
This interaction may be important in the process of wound healing.The gene encoding Phemx is located in an important tumor-suppressor gene region that has been associated with Beckwith-Wiedemann syndrome as well as a variety of cancers.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human TSPAN32.
