TSG6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family.
The hyaluronan-binding domain is involved in extracellular matrix stability and cell migration.
This protein forms a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhances the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation.
The expression of this gene can be induced by tumor necrosis factor alpha and interleukin-1.
The expression can also be induced by mechanical stimuli in vascular smooth muscle cells, and is correlated with proteoglycan synthesis and aggregation.
Applications:Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:Western Blot: 1:500-1:1000Immunohistochemistry (Paraffin): 1:50-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes endogenous levels of human TSG-6. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to the N-terminal of human TSG-6 (P98066).
