Vanilloid receptor 1 (VR1), also designated capsaicin receptor, is a nonselective cation channel, structurally related to members of the TRP family of ion channels.
VR1 is activated by capsaicin, the active ingredient in chili peppers, by heat and by an increase in protons at sites of infection, inflammation and ischemia.
By creating moderately acidic conditions, protons are able to lower the temperature threshold for VR1 activation, thus identifying VR1 as a molecular integrator of chemical and physical stimuli that elicit pain.
VR1 is expressed in primary sensory neurons and vagal nerves and activated VR1 induces the influx of cations, particularly Ca2+ and Na+ ions.
The vanilloid receptor may also be a molecular target for endogenous anandamide, in addition to the cannabinoid receptors, in the nervous and cardiovascular systems.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of TRPV1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human TRPV1.
