TRAF5 is a member of the TNF receptor associated factor (TRAF) protein family.
TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily.
TRAF5 is one of the components of a complex associated with the CD40 cytoplasmic domain, which mediates TNF induced NF-kappa B activation and protection from cell death.
TRAF5 influences signaling events by other receptors including CD27, CD30, and lymphotoxin-beta receptor.
TRAF5 plays a role in osteoclastogenesis.
Two alternatively spliced transcript variants encoding the same protein have been reported.
The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine-rich extracellular domains.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of TRAF5. Species Crossreactivity: Human, mouse, rat
