84-2407-65　［取扱停止］TPX2 (Targeting Protein for Xklp2, Differentially expressed in Cancerous and non-Cancerous lung Cells 2, DIL-2, HepatoCellular Carcinoma-Associated Antigen 519, Protein fls353, Restricted Expression Proliferation-Associated Protein 100, p100, TPX2, C20orf1, C20orf2, DIL2, HCA519) 100ul　226422

特徴

• TPX2 (targeting protein for Xklp2) is a microtubule-associated protein involved in targeting the motor protein Xklp2 to microtubules.
• Ran-GTP activates TPX2 for the chromatin-induced microbutule assembly during M phase.
• Aurora-A kinase associates with TPX2 at the spindle apparatus and may regulate TPX2 via phosphorylation during the spindle assembly.
• TPX2 appears to play a structural role in spindle formation.
• TPX2 activates Eg2 in a microtubuledependent manner by stimulating the phosphorylation and kinase activity of Eg2.
• TPX2 is inactivated by binding to importin alpha, a nuclear import factor.
• Finally, the suppression of TPX2 with RNA interference causes defects in microtubule organization during mitosis.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.