84-2407-07　［取扱停止］TNFSF13B (ApoL Related Ligand TALL 1, B Cell Activating Factor, B Lymphocyte stimulator, B-Cell-Activating Factor, BAFF, BLyS, CD 257, CD257, CD257 Antigen, Delta BAFF, Dendritic Cell derived TNF like Molecule, Dendritic Cell-derived TNF-like Molecule, DTL, DTL Precursor, PRO738, Soluble form, TALL 1, TALL-1, TALL1, THANK, TN13B_HUMAN, TNF and APOL Related leukocy ...　226391

特徴

• TNF cytokine family member TALL-1 (also designated BAFF, THANK and BLyS), is a type II membrane protein that shares characteristics with other members of the tumor necrosis factor (TNF) cytokine family.
• TALL-1 is expressed abun-dantly in peripheral blood leukocytes, monocytes and macrophages.
• TALL-1 is critically involved in the regulation of infections, inflammation, autoimmune diseases and tissue homeostasis.
• TALL-1 is a potent B cell stimulatory factor which is functionally involved in B cell proliferation and may be a primary mediator in B cell-associated autoimmune diseases.
• The C-terminal extracellular domain has b jelly roll topography and is important in ligand trimerization.
• The binding of the ligand to its respective receptor induces oligomerization, initiating downstream signaling events.
• Intrinsic to oligomerization is the formation of the receptor binding site at the junction between neighboring subunits, creating a multivalent ligand.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.