84-2406-93　［取扱停止］TNFRSF10D (CD 264, CD264, DcR 2, DcR2, Decoy Receptor 2, Decoy with truncated Death Domain, OTTHUMP00000123528, TNF Receptor Related Receptor for TRAIL, TNF Related Apoptosis inducing Ligand Receptor 4, TNF-Related Apoptosis-inducing Ligand Receptor 4, TNFRSF 10D, TNFRSF10D, TR10D_HUMAN, TRAIL R4, TRAIL Receptor 4, TRAIL Receptor with a truncated Death Domain, TRA ...　226385

特徴

• Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors, designated TNF-R1 and TNF-R2, which are expressed on most cell types.
• TNF function is primarily mediated through TNF-R1 signaling.
• Both receptors belong to the growing TNF receptor superfamily which includes FAS antigen and CD40.
• TNF-R1 contains a cytoplasmic motif, termed the “death domain,” that has been found to be necessary for the transduction of the apoptotic signal.
• The death domain is also found in several other receptors, including FAS, DR2 (or TRUNDD), DR3 (death receptor 3), DR4, DR5 and DR6.
• TRUNDD, DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL.
• Non-death domain-containing receptors, designated decoy receptor 1 (DcR1) or TRID, DcR2 and DcR3, associate with specific ligands and may play a role in cellular resistance to apoptotic stimuli.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.