Six human homologs of the Drosophila Toll receptor were initially identified based on their sequence similarities and designated Toll-like receptors (TLR).
TLR3 is highly expressed in placenta and pancreas, and is limited to the dendritic subpopulation of leukocytes.
TLR3 recognizes dsRNA associated with viral infection and induces activation of NFkB and production of type I interferons, which suggests that it may play a role in host defense against viruses.
TLR6 is highly homologous to TLR1, sharing greater than 65% sequence identity.
Like other members of TLR family, TLR6 induces NFkB signaling upon activation.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of TLR3. Species Crossreactivity: Human, mouse, rat
