Transketolase (TK or TKT), a member of the Transketolase family, is a multifunctional protein that plays a role in diabetes, cancer, Alzheimer’s disease and Wernicke-Korsakoff’s syndrome, a latent genetic neurological disorder.
Transketolase is also important for the prevention of hyperglycemia-induced vascular damage.
Transketolase is a crucial protein in the pentose phosphate pathway (PPP), where it catalyzes several reactions.
In combination with Transaldolase, Transketolase functions as a link between glycolysis and the non-oxidative part of the PPP, allowing the cell to adapt to varying metabolic conditions in response to environmental changes.
Transketolase activity is detected in small intestine epithelia, liver parenchyma, tongue, cornea and trachea.
It is also expressed in the proximal tubules of kidney and in ganglion cells in medulla of the adrenal gland.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of TKT. Species Crossreactivity: Human, mouse
