Involved in innate immunity against invading pathogens.
Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis.
Ligand binding to these receptors results in TRIF recruitment through its TIR domain.
Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of TICAM1. Species Crossreactivity: Human
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant full length Human TICAM1.
Shelf Life：1year
Swiss Prot Number：Q8IUC6
EU Commodity Code：30021010
商品名：TICAM1 (HSD34, MGC35334, Proline Rich vinculin and TIR Domain Containing Protein B, Proline-Rich, PRVTIRB, Putative NF kappa B Activating Protein 502H, Putative NF-kappa-B-Activating Protein 502H, Putative NFkB Activating Protein, Ring Finger Protein 36, RNF36, TCAM1, TICAM 1, TICAM-1, TICAM1, TIR Domain Containing Adapter Molecule 1, TIR Domain Containing Adapter Protein inducing IFN beta, TIR Domain Containing adaptor inducing interferon beta, TIR Domain-Containing Adapter Molecule 1, TIR Domain) 50ul
