84-2403-71　［取扱停止］TC1 (C8orf4, CH004_HUMAN, Chromosome 8 Open Reading Frame 4, Human Thyroid Cancer 1, MGC22806, TC-1, TC1, Thyroid Cancer Protein 1, Uncharacterized Protein C8orf4,) 100ul　226222

特徴

• TC1 (thyroid cancer protein 1), whose alternative names include C8orf4 or MGC22806, is a natively disordered and novel tumorigenic protein consisting of 106 amino acids that is known to associate with thyroid, gastric, and breast cancers.
• TC1 is ubiquitously expressed and may enhance the aggressive behavior of cancers by acting as an upstream regulator involved in positive regulation of the Wnt/beta-catenin signaling pathway.
• Upregulation of TC1 by mitogens and the ERK1/2 signaling pathway promotes the G1 to S-phase transition of the cell cycle.
• TC1 also plays a role as a novel heat shock response regulator that is upregulated by cellular stresses and heat shock.
• The gene encoding TC1 maps to human chromosome 8, which consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies including Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome and congenital hypothyroidism.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.